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Pregled bibliografske jedinice broj: 1055028

Differential DNA methylation of vocal and facial anatomy genes in modern humans

Gokhman, David; Nissim-Rafinia, Malka; Agranat-Tamir, Lily; Housman, Genevieve; García-Pérez, Raquel; Lizano, Esther; Cheronet, Olivia; Mallick, Swapan; Nieves-Colón, Maria A.; Li, Heng et al.
Differential DNA methylation of vocal and facial anatomy genes in modern humans // Nature Communications, 11 (2020), 1189, 21 doi:10.1038/s41467-020-15020-6 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1055028 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Differential DNA methylation of vocal and facial anatomy genes in modern humans

Autori
Gokhman, David ; Nissim-Rafinia, Malka ; Agranat-Tamir, Lily ; Housman, Genevieve ; García-Pérez, Raquel ; Lizano, Esther ; Cheronet, Olivia ; Mallick, Swapan ; Nieves-Colón, Maria A. ; Li, Heng ; Alpaslan-Roodenberg, Songül ; Novak, Mario ; Gu, Hongcang ; Josinski, Jason M. ; Ferrando-Bernal, Manuel ; Gelabert, Pere ; Lipende, Iddi ; Mjungu, Deus ; Kondova, Ivanela ; Bontrop, Ronald ; Kullmer, Ottmar ; Weber, Gerhard ; Shahar, Tal ; Dvir-Ginzberg, Mona ; Faerman, Marina ; Quillen, Ellen E. ; Meissner, Alexander ; Lahav, Yonatan ; Kandel, Leonid ; Liebergall, Meir ; Prada, María E. ; Vidal, Julio M. ; Gronostajski, Richard M. ; Stone, Anne C. ; Yakir, Benjamin ; Lalueza-Fox, Carles ; Pinhasi, Ron ; Reich, David ; Marques-Bonet, Tomas ; Meshorer, Eran ; Carmel, Liran

Izvornik
Nature Communications (2041-1723) 11 (2020); 1189, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Methylation ; anatomy ; vocal ; facial ; modern humans

Sažetak
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract.

Izvorni jezik
Engleski

Znanstvena područja
Arheologija



POVEZANOST RADA

Ustanove:
Institut za antropologiju

Profili:

Avatar Url Mario Novak (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Gokhman, David; Nissim-Rafinia, Malka; Agranat-Tamir, Lily; Housman, Genevieve; García-Pérez, Raquel; Lizano, Esther; Cheronet, Olivia; Mallick, Swapan; Nieves-Colón, Maria A.; Li, Heng et al.
Differential DNA methylation of vocal and facial anatomy genes in modern humans // Nature Communications, 11 (2020), 1189, 21 doi:10.1038/s41467-020-15020-6 (međunarodna recenzija, članak, znanstveni)
Gokhman, D., Nissim-Rafinia, M., Agranat-Tamir, L., Housman, G., García-Pérez, R., Lizano, E., Cheronet, O., Mallick, S., Nieves-Colón, M. & Li, H. (2020) Differential DNA methylation of vocal and facial anatomy genes in modern humans. Nature Communications, 11, 1189, 21 doi:10.1038/s41467-020-15020-6.
@article{article, author = {Gokhman, David and Nissim-Rafinia, Malka and Agranat-Tamir, Lily and Housman, Genevieve and Garc\'{\i}a-P\'{e}rez, Raquel and Lizano, Esther and Cheronet, Olivia and Mallick, Swapan and Nieves-Col\'{o}n, Maria A. and Li, Heng and Alpaslan-Roodenberg, Song\"{u}l and Novak, Mario and Gu, Hongcang and Josinski, Jason M. and Ferrando-Bernal, Manuel and Gelabert, Pere and Lipende, Iddi and Mjungu, Deus and Kondova, Ivanela and Bontrop, Ronald and Kullmer, Ottmar and Weber, Gerhard and Shahar, Tal and Dvir-Ginzberg, Mona and Faerman, Marina and Quillen, Ellen E. and Meissner, Alexander and Lahav, Yonatan and Kandel, Leonid and Liebergall, Meir and Prada, Mar\'{\i}a E. and Vidal, Julio M. and Gronostajski, Richard M. and Stone, Anne C. and Yakir, Benjamin and Lalueza-Fox, Carles and Pinhasi, Ron and Reich, David and Marques-Bonet, Tomas and Meshorer, Eran and Carmel, Liran}, year = {2020}, pages = {21}, DOI = {10.1038/s41467-020-15020-6}, chapter = {1189}, keywords = {Methylation, anatomy, vocal, facial, modern humans}, journal = {Nature Communications}, doi = {10.1038/s41467-020-15020-6}, volume = {11}, issn = {2041-1723}, title = {Differential DNA methylation of vocal and facial anatomy genes in modern humans}, keyword = {Methylation, anatomy, vocal, facial, modern humans}, chapternumber = {1189} }
@article{article, author = {Gokhman, David and Nissim-Rafinia, Malka and Agranat-Tamir, Lily and Housman, Genevieve and Garc\'{\i}a-P\'{e}rez, Raquel and Lizano, Esther and Cheronet, Olivia and Mallick, Swapan and Nieves-Col\'{o}n, Maria A. and Li, Heng and Alpaslan-Roodenberg, Song\"{u}l and Novak, Mario and Gu, Hongcang and Josinski, Jason M. and Ferrando-Bernal, Manuel and Gelabert, Pere and Lipende, Iddi and Mjungu, Deus and Kondova, Ivanela and Bontrop, Ronald and Kullmer, Ottmar and Weber, Gerhard and Shahar, Tal and Dvir-Ginzberg, Mona and Faerman, Marina and Quillen, Ellen E. and Meissner, Alexander and Lahav, Yonatan and Kandel, Leonid and Liebergall, Meir and Prada, Mar\'{\i}a E. and Vidal, Julio M. and Gronostajski, Richard M. and Stone, Anne C. and Yakir, Benjamin and Lalueza-Fox, Carles and Pinhasi, Ron and Reich, David and Marques-Bonet, Tomas and Meshorer, Eran and Carmel, Liran}, year = {2020}, pages = {21}, DOI = {10.1038/s41467-020-15020-6}, chapter = {1189}, keywords = {Methylation, anatomy, vocal, facial, modern humans}, journal = {Nature Communications}, doi = {10.1038/s41467-020-15020-6}, volume = {11}, issn = {2041-1723}, title = {Differential DNA methylation of vocal and facial anatomy genes in modern humans}, keyword = {Methylation, anatomy, vocal, facial, modern humans}, chapternumber = {1189} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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