Naslov
Incidence and type of Carbapenemase-Producing Enterobacteria in a tertiary care hospital

Autori
Ratković, Dea ; Repac Antić, Davorka ; Škrobonja, Ivana ; Bubonja Šonje, Marina ; Ambrožić, Damir ; Abram, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Knjiga sažetaka / - , 2019

Skup
12. Hrvatski kongres kliničke mikrobiologije ; 9. Hrvatski kongres o infektivnim bolestima (CROCMID 2019)

Mjesto i datum
Split, Hrvatska, 24.10.2019. - 27.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Carbapenemase-Producing Enterobacteria ; incidence ; tertiary care hospital

Sažetak
Aim: The aim of our study was to determine incidence and type of carbapenemase producing enterobacteria (CPE) as well as its distribution by wards in Clinical Hospital Centre (CHC) Rijeka. Materials and Methods: This retrospective study was carried out in the Department of Clinical Microbiology, CHC Rijeka. CPE strains were isolated in different clinical samples sent to the laboratory for microbiological testing. Species identification was performed using the Vitek 2 system (BioMérieux, France). The isolates were tested against imipenem, meropenem, and ertapenem by disk diffusion and MIC assays. For strains showing reducing susceptibility to any carbapenem, a carbapenemase confirmation test was conducted using discs Combi Carba Plus (Mast Group, Great Britain), and the Xpert Carba-R assay (Cepheid, California) according to the manufacturer’s instructions. Results: From January 2013 to the end of June 2019, 131 CPE were detected. The majority (81%) of the strains were isolated from surveillance cultures (rectal swab, urine, endotracheal aspirate) referring to colonization thus identifying potential carriers who may serve as reservoirs for sustained horizontal transmission. The most commonly affected wards were intensive care, neurology and neurosurgery, where severe patients are generally treated for a prolonged time. It should be noted that CPE have significantly increased in recent years. From the beginning of 2018, 113 CPE were isolated which is 86% of the total number of CPE strains detected during the period covered. The most common CPE were Klebsiella pneumoniae OXA- 48-like (55%) following by Enterobacter cloacae NDM (20%). Conclusion: Reliable detection of carbapenemase production is an essential first step in combating this problem. Differentiation between the various carbapenemase families may also be useful, not only to inform epidemiology but also to guide patient treatment. Early detection of CPE and implementation of strict infection control measures are essential to control the spread of these multidrug-resistant organisms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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