Naslov
Knowledge discovery of drug data on the example of adverse reaction prediction
(Knowledge discovery of drug data on the example of adverse reaction prediction)

Autori
Yildirim, Pinar ; Majnarić, Ljiljana ; Ekmekci, Ozgur Ilyas ; Holzinger, Andreas

Izvornik
BMC Bioinformatics (1471-2105) 15 (2014), S6; S7-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibiotics prescription, children, adverse drug reactions, health records, clusters, knowledge discovery

Sažetak
Background: Antibiotics are the widely prescribed drugs for children and most likely to be related with adverse reactions. Record on adverse reactions and allergies from antibiotics considerably affect the prescription choices. We consider this a biomedical decision-making problem and explore hidden knowledge in survey results on data extracted from a big data pool of health records of children, from the Health Center of Osijek, Eastern Croatia. Results: We applied and evaluated a k-means algorithm to the dataset to generate some clusters which have similar features. Our results highlight that some type of antibiotics form different clusters, which insight is most helpful for the clinician to support better decision-making. Conclusions: Medical professionals can investigate the clusters which our study revealed, thus gaining useful knowledge and insight into this data for their clinical studies.

Izvorni jezik
Engleski

POVEZANOST RADA