Naslov
Resistance to cephalosporins among leading causes of community – acquired urinary tract infections

Autori
Barišić, Zvonimir ; Borzić, Elmica ; Carev, Merica ; Kaliterna, Vanja ; Šiško Kraljević, Katarina ; Zoranić, Vinko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstract book and final programme of Symposium "Appropriate use of antimicrobials in hospitals and community" / - Bled : International Society of Chemotherapy, FESCI, Slovenian Society of Chemotherapy, 2005, 60-61

Skup
Symposium "Appropriate use of antimicrobials in hospitals and community"

Mjesto i datum
Bled, Slovenija, 13.10.2005. - 15.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
UTI ; cephalosporins

Sažetak
Objectives. The aim of this research is to determine resistance rates to cephalosporins among Gram-negative bacteria leading causes of community - acquired urinary tract infections (UTI) in population of Split and Dalmatia County, Croatia as well as define their place in the treatment of outpatients with UTI, comparing their activity with antimicrobials usually used in treatment of UTI. Materials and methods. In this study 1035 consecutive, nonduplicate isolates of Gram- negative uropathogens were collected from urine of symptomatic outpatients during a 3-month-period in 2005. Identification up to the species level was made by both conventional biochemical methods and API10E (bioMerieux, France). Antibiotic susceptibility to oral representatives of three cephalosporin-generations (cefalexin CN, cefuroxim CXM, cefixime CFX) as well as some other oral drugs used in treatment of UTI (ampicillin AMX, trimethoprim / sulphamethoxazole STX and norfloxacin NOR) was made by disk diffusion method. Results. During the observed period, 1035 isolates belonged to Gram-negative bacteria. Among them, the most common isolates were Escherichia coli (58.35% from overall number of isolates), followed by Klebsiella spp. (8.16%), Proteus mirabilis (7.62%) and Pseudomonas spp. (3.00%). Resistance rates (in percents) are shown in table. Resistance rates of Pseudomonas strains for cefixime and norfloxacin were 84.62 and 38.46, respectively. Conclusions. Leading Gram-negative uropathogens, with exception of Pseudomonas, showed very good susceptibility to all tested cephalosporins, especially to cefixime, member of third generation, recently introduced into the Croatian drug market. According to good in vitro results, they could be good therapeutic option for community - acquired UTI ; however, in order to evaluate their place in the treatment it is necessary to perform further clinical studies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA