Naslov
Changes in antimicrobial resistance of urinary Escherichia coli isolates during 5-year period

Autori
Barišić, Zvonimir ; Borzić, Elmica ; Šiško Kraljević, Katarina ; Carev, Merica ; Kaliterna, Vanja ; Zoranić, Vinko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Program i knjiga sažetaka 7. hrvatskog kongresa kliničke mikrobiologije i infektologije / Šubić Škrlin, Jasenka - Zagreb : Hrvatsko društvo za medicinsku mikrobiologiju i parasitologiju Hrvatskog liječničkog zbora, 2005, 80-80

Skup
7. hrvatski kongres kliničke mikrobiologije i infektologije

Mjesto i datum
Zagreb, Hrvatska, 18.05.2005. - 21.05.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Urinary tact infectins ; E.coli ; antimicrobial resistance

Sažetak
Urinary tract infections are very common infections in humans, with Escherichia coli as dominant pathogen. It is usual to treat patients with uncomplicated bacterial cystitis using empirical antimicrobial therapy, according to known local resistance rates, Surveillance of local resistance rates is very important for providing appropriate ernpincal therapy. Study was performed in Split and Dalmatia County, Croatia. All E. coli strains isolated in January 1999 (645 strains) and in January 2004 (715 strains) from urine samples of symptomatic outpatients with more than 104 CFU/ml and with significant leucocyturia (4-5 leucocytes/ field) were included in the study. Isolation of E. coli strains from urine specimens was performed by a surface streak procedure on CLED agar (Biolife, Milan, Italy). Identification was performed by conventional biochemical tests and susceptibility testing was done by standard disk diffusion method according to the NCCLS guidelines (1998 and 2003), Tested antimicrobial agents were amoxycillin, cefuroxime, nitrofurantoin, trimethoprim/ sulphamethoxazole and ciprofloxacin (disks produced by Bio-Rad. Mames-Ia-Coquetle, France). Chi-square analysis was used for determination of statistical significance in antimicrobial resistance changes over a 5-year period. In 1999 resistance rate for amoxycillin was 42, 33%, for cefuroxime 0, 93%, for nitrofurantoin 1.14%, for trimethoprim/sulphamethoxazole 19, 68% and for- ciprofloxacin 2, 48% and in 2004 resistance rates were 41, 40%, 0, 98%, 1, 68%, 21, 82% and 7, 27% respectively. Statistically significant change in antimicrobial resistance rates over a 5-year period was noted only for ciprofloxacin (P < 0, 001). E. coli showed a slow but steady increase of resistance to several antimicrobial drugs. Resistance rates of amoxycillin and trimethoprim/sulphamethoxazole reached the levels that excluded them as empiric choice in treatment of UTI. The most concerning result obtained in this study was almost a 3-fold increase in resistance to ciprofloxacin in 5-year- period, This trend is present throughout the world and is related to increased use of quinolones. Monitoring of local epidemiology of uropathogens is essential for providing appropriate empirical therapy for our patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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