Naslov
Novel ruthenium amide conjugates as potential anticancer compounds

Autori
Opačak, Saša ; Landais, Corentin ; Pernar, Margareta ; Brozović, Anamarija ; Kirin, Srećko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjige sažetaka (SMLKI) / Dejanović, Igor ; Vrsaljko, Domagoj ; Žižek, Krunoslav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2020, 175-175

ISBN
978-953-6894-71-0

Skup
XIII. susret mladih kemijskih inženjera (SMLKI 2020)

Mjesto i datum
Zagreb, Hrvatska, 20.02.2020. - 21.02.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
Ruthenium ; amide ; cancer ; hella cells

Sažetak
Cancer is the second leading cause of death globally accounting for one out of six disease related deaths.[1] Platinum drugs are most commonly applied in cancer treatment but exhibit numerous side effects. [2] In order to mitigate these side effect ruthenium organometallics have been developed as promising alternatives. Although no ruthenium compounds are currently in clinical usage, a number of compounds show superior properties over platinumbased drugs. [3] In our previous work [4] ruthenium(II) complexes of amino acid phosphine bioconjugates have shown relevant cytotoxic activity with selectivity towards tumour cells. Herein, we expand this work and present derivatives 1 and 2 (Fig 1) with one formally isomerised amide bond, inspired by our enantioselective catalysts. [5] The newly synthesised compounds were characterised by various spectroscopic methods and their biological properties were explored in HeLa cells

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA