Naslov
Catestatin and chronic heart failure patients with an acute decompensation event: clinical characteristics and 30-day all-cause mortality

Autori
Borovac, Josip Anđelo ; Glavas, D ; Susilovic Grabovac, Z ; Rusic, D ; Stanisic, L ; Bradaric, A ; Ticinovic Kurir, T ; Bozic, J

Kolaboracija
CATSTAT-HF

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European Heart Journal / - : Oxford University Press, 2019, 3335-3335

Skup
European Society of Cardiology Congress 2019 ; World Congress of Cardiology 2019

Mjesto i datum
Pariz, Francuska, 31.08.2019. - 04.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
catestatin ; chronic heart failure

Sažetak
Background: Catestatin (CST) is a cardiovascular regulator with pleiotropic systemic functions that might affect the course of acutely decompensated heart failure (ADHF). Purpose: To determine the association of serum CST with the 30-day all-cause mortality and to compare clinical and laboratory parameters between ADHF patients within the lowest vs. highest quartile of CST concentration. Methods: Eighty-two consecutive ADHF patients, as adjudicated per ESC 2016 HF criteria, were enrolled in the study during 2018–2019. Results: Mean age of the enrolled cohort was 70.8±9.3 years and 54.9% were women. Seventy percent of patients were in NYHA III functional class and nearly half had a reduced LVEF. Median CST value was 5.6 ng/mL (IQR 3, 12). During the 30-day follow-up, ten patients died (12.2%) due to all causes. CST levels were significantly higher among patients that died compared to survivors (21.9±6.3 vs. 10.2±1.5 ng/mL, p=0.0139, respectively). Patients in the highest CST quartile had higher mortality and disease burden accompanied by more prominent laboratory abnormalities, compared to patients in the lowest CST quartile. Compared groups did not significantly differ in terms of dosages and type of baseline HF pharmacotherapy. Conclusions: Higher levels of catestatin measured during the hospitalization event among ADHF patients are associated with 30-day all- cause mortality and worse in-hospital profile thus might facilitate short-term prognosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA