Naslov
Vaccine Adjuvants Derivatized from Momordica Saponins I and II

Autori
Wang, Pengfei ; Ding, Xiong ; Kim, Hyunjung ; Škalamera, Đani ; Michalek, Suzanne M. ; Zhang, Ping

Izvornik
Journal of medicinal chemistry (0022-2623) 62 (2019), 21; 9976-9982

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immunoadjuvants, Momordica saponins, organic synthesis, carbohydrate chemistry, natural product synthesis

Sažetak
We have derivatized Momordica saponins (MS) I and II through their coupling at C3 glucuronic acid site with dodecylamine. The derivatives show significantly different immunostimulant activity profiles from their respective natural parent saponins. In particular, adjuvant VSA-1 (5), the derivative of MS I, potentiates a significantly higher IgG2a responose than the corresponding natural product. Its IgG1 and IgG2a production is similar to that of GPI- 0100, indicating a potential mixed and antigen- specific Th1/Th2 immune response, which is different from the Th2 immunity induced by the natural saponin MS I. In addition, toxicity evaluations show that adjuvant VSA-1 (5) is much less toxic than the widely used natural saponin mixture Quil A. These results prove that derivatizing Momordica saponins can be a viable way for easy access to structurally defined saponin immunostimulants with favorable adjvuant activity and low toxicity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA