Pregled bibliografske jedinice broj: 1052079
Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants
Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants // ACS Infectious Diseases, 5 (2019), 6; 974-981 doi:10.1021/acsinfecdis.9b00039 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1052079 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants
Autori
Wang, Pengfei ; Škalamera, Đani ; Sui, Xianwei ; Zhang, Ping, Michalek, Suzanne M.
Izvornik
ACS Infectious Diseases (2373-8227) 5
(2019), 6;
974-981
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
immunoadjuvants ; Quillaja saponaria ; organic synthesis ; carbohydrate chemistry ; natural product synthesis
Sažetak
We have designed and synthesized two analogs (5 and 6) of QS-7, a natural saponin compound isolated from Quillaja saponaria (QS) Molina tree bark. The only structural difference between compound 5 and 6 is that 5 is acetylated at the 3- and 4-O positions of the quillaic acid C28 fucosyl unit while 6 is not. However, the two analogs show significantly different immunostimulant profiles. Compound 5 may potentiate a mixed Th1/Th2 (Th, T helper cells) immune response against the specific antigens while compound 6 may only induce a Th2-biased immunity. These results suggest that the 3- and/or 4-O acetyl groups of the fucosyl unit may play an important role in tuning the adjuvanticity of the QS-7 analogs, and compound 5 can serve as a structurally defined synthetic adjuvant when a mixed Th1/Th2 immune responses is desired.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
