Pregled bibliografske jedinice broj: 1052072
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant // Journal of medicinal chemistry, 62 (2019), 3; 1669-1676 doi:10.1021/acs.jmedchem.8b01997 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1052072 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant
Autori
Wang, Pengfei ; Škalamera, Đani ; Sui, Xianwei ; Zhang, Ping ; Michalek, Suzanne M.
Izvornik
Journal of medicinal chemistry (0022-2623) 62
(2019), 3;
1669-1676
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
immunoadjuvants ; Quillaja saponaria ; organic synthesis ; carbohydrate chemistry ; natural product synthesis
Sažetak
We have synthesized QS-17/18 analog 7 and evaluated its adjuvant activity in the formulation with rHagB antigen. Compound 7 and QS-21 analogs 5 and 6 are presumably the major components of the widely studied semi-synthetic saponin adjuvant mixture GPI-0100. Based on its IgG subclass antibody response assessments, adjuvant 7 shows an adjuvant activity profile similar to that of GPI-0100 which potentiates a mixed Th1- and Th2-like response to rHagB. Their profiles are different from those of QS21 analogs 5 and 6 that probably only induce a Th2-like immunity. Combination of QS-21 and QS- 17/18 analogs does not show a synergistical effect. These results suggest that compound 7 might be the main active component of GPI-0100 and is responsible for the favorable adjuvant property of GPI-0100.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
