Pregled bibliografske jedinice broj: 1051580
In Vivo Fitness Costs of Different Gag CD8 T-Cell Escape Mutant Simian-Human Immunodeficiency Viruses for Macaques
In Vivo Fitness Costs of Different Gag CD8 T-Cell Escape Mutant Simian-Human Immunodeficiency Viruses for Macaques // Journal of Virology, 81 (2007), 10; 5418-5422 doi:10.1128/jvi.02763-06 (međunarodna recenzija, članak, znanstveni)
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Naslov
In Vivo Fitness Costs of Different Gag CD8 T-Cell Escape Mutant Simian-Human Immunodeficiency Viruses for Macaques
Autori
Loh, L. ; Batten, C. J. ; Petravic, J. ; Davenport, M. P. ; Kent, S. J.
Izvornik
Journal of Virology (0022-538X) 81
(2007), 10;
5418-5422
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
HIV, immune escape ; reversion
Sažetak
He kinetics of immune escape and reversion depend upon the efficiency of CDS cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable ; those of KP9 and AF9 were faster than those of KW9. Kinetics of reversion of escape mutant virus to wild type upon passage to naïve major histocompatibility complesmismatched macaques also varied. Rapid reversion occurred at KP9, gradual biphasic reversion occurred at AF9, and escape mutant KW9 virus failed to revert. The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia.
Izvorni jezik
Engleski
Znanstvena područja
Matematika, Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
