Pregled bibliografske jedinice broj: 1051562
Rates of HIV immune escape and reversion: implications for vaccination
Rates of HIV immune escape and reversion: implications for vaccination // Trends in Microbiology, 16 (2008), 12; 561-566 doi:10.1016/j.tim.2008.09.001 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1051562 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Rates of HIV immune escape and reversion: implications for vaccination
Autori
Davenport, Miles P. ; Loh, Liyen ; Petravic, Janka ; Kent, Stephen J.
Izvornik
Trends in Microbiology (0966-842X) 16
(2008), 12;
561-566
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
HIV, immune escape ; reversion
Sažetak
HIV-1 mutates extensively in vivo to escape immune control by CD8+ T cells (CTLs). The CTL escape mutant virus might also revert back to wild-type upon transmission to new hosts if significant fitness costs are incurred by the mutation. Immune escape and reversion can be extremely fast if they occur very early after infection, whereas they are much slower when they begin later during infection. Immune escape presents a significant barrier to vaccination, because escape of vaccine-mediated immune responses could neutralise any benefits of vaccination. Here, we consider the dynamics of immune escape and reversion in vivo in natural infection, and suggest how understanding of this can be used to predict optimal vaccine targets and design vaccination strategies that maximise immune control. We predict that inducing synchronous, broad CTL by vaccination should limit the likelihood of viral escape from immune control.
Izvorni jezik
Engleski
Znanstvena područja
Matematika, Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
