Naslov
Improvement of endothelial function by pitavastatin: a meta-analysis

Autori
Katsiki, Niki ; Reiner, Željko ; Tedeschi Reiner, Eugenia ; Al-Rasadi, Khalid ; Pirro, Matteo ; Mikhailidis, Dimitri P. ; Sahebkar, Amirhossein

Izvornik
Expert opinion on pharmacotherapy (1465-6566) 19 (2018), 3; 279-286

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
Pitavastatin ; endothelial function ; flow-mediated dilation ; atherosclerosis ; meta-analysis

Sažetak
Objective. Dyslipidemia is commonly associated with endothelial dysfunction and increased cardiovascular risk. Pitavastatin has been shown to reduce total and low-density lipoprotein cholesterol, to increase high- density lipoprotein (HDL)-cholesterol and improve HDL function. Furthermore, several trials explored its effects on flow-mediated dilation (FMD), as an index of endothelial function. The authors evaluated the effect of pitavastatin therapy on FMD.Methods. The authors performed a systematic review and meta- analysis of all clinical trials exploring the impact of pitavastatin on FMD. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics.Results. Six eligible studies comprising 7 treatment arms were selected for this meta-analysis. Overall, WMD was significant for the effect of pitavastatin on FMD (2.45%, 95% CI: 1.31, 3.60, p<0.001) and the effect size was robust in the leave-one-out sensitivity analysis.Conclusion. This meta-analysis of all available clinical trials revealed a significant increase of FMD induced by pitavastatin

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA