Naslov
PCSK9 and infection: A potentially useful or dangerous association?

Autori
Khademi, Farzad ; Momtazi-borojeni, Amir Abbas ; Reiner, Željko ; Banach, Maciej ; Al-Rasadi, Khalid Al ; Sahebkar, Amirhossein

Izvornik
Journal of Cellular Physiology (0021-9541) 233 (2017), 4; 2920-2927

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LDL receptor ; PCSK9 ; cholesterol ; hepatitis C virus ; infection

Sažetak
Elevated plasma low-density lipoprotein- cholesterol (LDL-C) concentration is the most important risk factor for atherosclerotic cardiovascular diseases (CVDs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a ubiquitously expressed serine proteinase which plays a key role in cholesterol metabolism, but has been found to be implicated in some other lipid-independent physiological processes. In this review, the role of PCSK9 was evaluated not only concerning lipid metabolism but also hepatitis C virus (HCV) infection, bacterial infections/sepsis, and septic shock. Collected data from clinical trials revealed that treatment with PCSK9 inhibitors has beneficial effects in lowering LDL-C via inhibition of LDL-receptors (LDL-R), an antiviral effect on HCV infection via down-regulating the surface expression of LDL-R and CD81 on hepatic cells, and a positive association with increased inflammatory responses, as well as with septic shock by down-regulation of hepatocyte LDL-R. On the other hand, PCSK9 inhibition by therapeutic fully humanized antibodies has positive effects in reducing elevated LDL-C. However, their safety and tolerability is an important issue which has to be taken into consideration

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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