Naslov
Assessing patient-reported quality of life outcomes in vulva cancer patients: a systematic literature review
(Assessing patient-reported quality of life outcomes in vulva cancer patients: a systematic literature review)

Autori
Froeding, Ligita Paskeviciute ; Greimel, Elfriede ; Lanceley, Anne ; Oberguggenberger, Anne ; Schmalz, Claudia ; Radisic, Vesna Bjelic ; Nordin, Andy ; Galalaei, Razvan ; Kuljanic, Karin ; Vistad, Ingvild ; Schnack, Tine Henrichsen ; Jensen, Pernille Tine

Izvornik
International journal of gynecological cancer (1048-891X) 28 (2018), 4; 808-817

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
vulva cancer ; quality of life ; questionnaire ; late effects

Sažetak
Objectives Vulva cancer (VC) treatment carries a high risk of severe late effects that may have a negative impact on quality of life (QoL). Patient- reported outcome measures (PROMs) are increasingly used when evaluating disease- and treatment- specific effects. However, the adequacy of measures used to assess sequelae and QoL in VC remains unclear. The aims of the present study were to evaluate disease- and treatment-related effects as measured by PROMs in VC patients and to identify available VC-specific PROMs. Methods/Materials A systematic literature search from 1990 to 2016 was performed. The inclusion criterion was report of disease- and treatment- related effects in VC patients using PROMs in the assessment. Methodological and reporting quality was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. This systematic review was performed as part of phase 1 of the development of a European Organisation for Research and Treatment of Cancer QoL questionnaire for VC patients. Results The search revealed 2299 relevant hits, with 11 articles extracted including a total of 535 women with VC ; no randomized controlled trials were identified. The selected studies exhibited great heterogeneity in terms of PROMs use. Twenty-one different instruments assessed QoL. Most of the questionnaires were generic. Different issues (sexuality, lymphedema, body image, urinary and bowel function, vulva-specific symptoms) were reported as potentially important, but the results were not systematically collected. Only one VC- specific questionnaire was identified but did not allow for assessment and reporting on a scale level. Conclusions Vulva cancer treatment is associated with considerable morbidity deteriorating QoL. To date, there is no validated PROM available that provides adequate coverage of VC-related issues. The study confirms the need for a VC-specific QoL instrument with sensitive scales that allows for broad cross-cultural application for use in clinical trials

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA