Pregled bibliografske jedinice broj: 1049599
Thymus Regeneration and Future Challenges
Thymus Regeneration and Future Challenges // Stem cell reviews and reports, 16 (2020), 239-250 doi:10.1007/s12015-020-09955-y (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1049599 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Thymus Regeneration and Future Challenges
Autori
Shichkin, Valentin P. ; Antica, Mariastefania
Izvornik
Stem cell reviews and reports (2629-3269) 16
(2020);
239-250
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Stem cells ; Thymus ; Thymectomised patients ; Thymus regeneration ; Thymic epithelial stem cells ; Small chemical compounds
Sažetak
Thymus regenerative therapy implementation is severely obstructed by the limited number and expansion capacity in vitro of tissue-specific thymic epithelial stem cells (TESC). Current solutions are mostly based on growth factors that can drive differentiation of pluripotent stem cells toward tissue-specific TESC. Target- specific small chemical compounds represent an alternative solution that could induce and support the clonal expansion of TESC and reversibly block their differentiation into mature cells. These compounds could be used both in the composition of culture media designed for TESC expansion in vitro, and in drugs development for thymic regeneration in vivo. It should allow reaching the ultimate objective - autologous thymic tissue regeneration in paediatric patients who had their thymus removed in the course of cardiac surgery.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
