Naslov
Expression of leucocytes following myocardial infarction is modulated by white wine consumption

Autori
Grković, Ivica ; Ključević, Nikola ; Milat, Ana Marija ; Jurić, Diana ; Mudnić, Ivana ; Boban, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / - Lahti, 2019, 311-312

ISBN
978 285 038 0105

Skup
42nd Congress of Vine and Wine

Mjesto i datum
Ženeva, Švicarska, 15.07.2019. - 19.07.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Myocardial infarction ; White wine consumption

Sažetak
A permanent coronary ligation was performed to determine how moderate white wine consumption, with low and high phenolic content, modulates inflammatory cells infiltration of the ischemic myocardium. Male Sprague-Dawley rats were given either a combination of different white wines and water or water only, for 28 days. Following coronary ligation, animals were kept alive for 24 hours. Five areas of myocardial wall were analysed -infarct/ischemic zone, three peri- infarct/border zones and a control/non-ischemic zone -to determine the expression of immunoreactivity for myeloperoxidase (MPO)- neutrophils marker and cluster of differentiation 68 (CD68)- macrophages marker. Significantly smaller expression for both MPO and CD68 was found in all three peri-infarct zones of wine drinking animals (p<0.001). There was no difference in expression of leukocyte markers between animals drinking standard and polyphenol- rich white wine, although for CD68, a non- significant attenuation was noticed in the latter. The wine drinking inflammatory attenuation was comparable to the effect of post- ischemic reperfusion or to the effects of some anti-inflammatory medications. We conclude that white wine consumption positively modulates peri- infarct inflammatory infiltration and we expect that this effect will be conveyed to later phases of infarct healing.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA