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Pregled bibliografske jedinice broj: 1048010

Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy

Logiodice, Federica; Lombardelli, Letizia; Kullolli, Ornela; Haller, Herman; Maggi, Enrico; Rukavina, Daniel; Piccinni, Marie-Pierre
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy // International Journal of Molecular Sciences, 20 (2019), 2; 48, 18 doi:10.3390/ijms20020428 (međunarodna recenzija, članak, znanstveni)

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Naslov
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy

Autori
Logiodice, Federica ; Lombardelli, Letizia ; Kullolli, Ornela ; Haller, Herman ; Maggi, Enrico ; Rukavina, Daniel ; Piccinni, Marie-Pierre

Izvornik
International Journal of Molecular Sciences (1422-0067) 20 (2019), 2; 48, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Th22 ; Th17 ; pregnancy ; IL-22 ; IL-4 ; IL-5 ; IL-17 ; spontaneous abortion ; ectopic pregnancy ; implantation

Sažetak
Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. In those experiencing successful pregnancy and those experiencing unexplained recurrent abortion (URA), the levels of IL-22 produced by decidual CD4+ T cells are higher than those of peripheral blood T cells. We found a correlation of IL-22 and IL-4 produced by decidual CD4+ T cells in those experiencing successful pregnancy, not in those experiencing URA. The correlation of IL-22 and IL-4 was also found in the serum of successful pregnancy. A prevalence of CD4+ T cells producing IL-22 and IL-4 (Th17/Th2/IL-22+, Th17/Th0/IL-22+, Th17/Th2/IL-22+, and Th0/IL-22+ cells) was observed in decidua of those experiencing successful pregnancy, whereas Th17/Th1/IL-22+ cells, which do not produce IL-4, are prevalent in those experiencing URA. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells are exclusively present at the embryo implantation site where IL-4, GATA-3, IL-17A, ROR-C, IL-22, and AHR mRNA are expressed. T-bet and IFN- mRNA are found away from the implantation site. There is no pathogenic role of IL-22 when IL-4 is also produced by decidual CD4+ cells. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells seem to be crucial for embryo implantation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Fakultet zdravstvenih studija u Rijeci

Profili:

Avatar Url Daniel Rukavina (autor)

Avatar Url Herman Haller (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Logiodice, Federica; Lombardelli, Letizia; Kullolli, Ornela; Haller, Herman; Maggi, Enrico; Rukavina, Daniel; Piccinni, Marie-Pierre
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy // International Journal of Molecular Sciences, 20 (2019), 2; 48, 18 doi:10.3390/ijms20020428 (međunarodna recenzija, članak, znanstveni)
Logiodice, F., Lombardelli, L., Kullolli, O., Haller, H., Maggi, E., Rukavina, D. & Piccinni, M. (2019) Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy. International Journal of Molecular Sciences, 20 (2), 48, 18 doi:10.3390/ijms20020428.
@article{article, author = {Logiodice, Federica and Lombardelli, Letizia and Kullolli, Ornela and Haller, Herman and Maggi, Enrico and Rukavina, Daniel and Piccinni, Marie-Pierre}, year = {2019}, pages = {18}, DOI = {10.3390/ijms20020428}, chapter = {48}, keywords = {Th22, Th17, pregnancy, IL-22, IL-4, IL-5, IL-17, spontaneous abortion, ectopic pregnancy, implantation}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms20020428}, volume = {20}, number = {2}, issn = {1422-0067}, title = {Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy}, keyword = {Th22, Th17, pregnancy, IL-22, IL-4, IL-5, IL-17, spontaneous abortion, ectopic pregnancy, implantation}, chapternumber = {48} }
@article{article, author = {Logiodice, Federica and Lombardelli, Letizia and Kullolli, Ornela and Haller, Herman and Maggi, Enrico and Rukavina, Daniel and Piccinni, Marie-Pierre}, year = {2019}, pages = {18}, DOI = {10.3390/ijms20020428}, chapter = {48}, keywords = {Th22, Th17, pregnancy, IL-22, IL-4, IL-5, IL-17, spontaneous abortion, ectopic pregnancy, implantation}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms20020428}, volume = {20}, number = {2}, issn = {1422-0067}, title = {Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy}, keyword = {Th22, Th17, pregnancy, IL-22, IL-4, IL-5, IL-17, spontaneous abortion, ectopic pregnancy, implantation}, chapternumber = {48} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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