Naslov
Quantitative modeling of cognitive decline

Autori
Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Marie Curie Action: Workshop on Quantitative Modeling in Biomedicine

Mjesto i datum
Zagreb, Hrvatska, 05.06.2017. - 07.06.2017

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
healthy aging ; cognitive decline ; longevity ; molecular mechanisms ; epigenetics ; epigenetic drifts ; mortality curves ; progeroid syndromes ; genetic influence on lifespan and longevity ; experimental models of aging ; quantitative modeling of cognitive decline ; subjective cognitive impairment ; mild cognitive impairment ; dementia

Sažetak
In my talk I will summarize the recent state-of-the-art of the following seven topics: 1. Molecular mechanisms of aging from cells to organisms: evolutionary theories of aging, theoretical models of aging, Gompertz-Makeham mortality curves, and progeroid syndromes, 2. Genetic influence on lifespan and longevity: results from twin studies ; neurodevelopmental origin of individual differences in cortical architecture in middle-aged adults: genetic dependence of cortical thickness, 3. Experimental models of aging in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus, 4. Genome-wide association studies of cognitive capabilities and educational attainment: heritability and polygenic nature of human intelligence (with emphasis on differences between crystallized and fluid-type intelligence), 5. Clinical variables and biomarkers in prediction of cognitive decline and slowing of perceptual processing speed in older adults using logistic, linear, and multivariate regression models, 6. Subjective cognitive impairment, imaging cognitive decline by visualization of brain atrophy (MRI) and decreased functional connectivity and metabolic activity (fMRI, PET), differential diagnosis of minor neurocognitive disorder (mild cognitive impairment) and major neurocognitive disorder (dementia), synaptic reserve, digital dementia, and 7. Horvath’s and Hannum’s epigenetic aging clocks and their applications: positive and negative epigenetic drifts, risk factors and epigenetic rejuvenation (reversibility of epigenetic changes and reprogramming of aged cells), and epigenetic prediction of time to death.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Računarstvo, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)

POVEZANOST RADA