Naslov
Event-related potentials improve diagnosis of Alzheimer’s disease

Autori
Babić Leko, Mirjana ; Krbot Skorić, Magdalena ; Klepac, Nataša ; Borovečki, Fran ; Langer Horvat, Lea ; Vogrinc, Željka ; Sonicki, Zdenko ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th FENS Forum of Neuroscience Book of Abstracts / - , 2018, 1507-1507

Skup
11th FENS Forum of Neuroscience

Mjesto i datum
Berlin, Njemačka, 07.07.2018. - 11.07.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease ; mild cognitive impairment ; early diagnosis ; differential diagnosis ; event-related potentials ; P300 potential ; N200 potential (ERP) ; reaction time (RT) ; cerebrospinal fluid ; biomarkers

Sažetak
The aim of this study is to improve the early and differential diagnosis of Alzheimer's disease (AD) by combining event-related potentials (ERP) measured non-invasively by electroencephalography (EEG) with biomarkers measured in the cerebrospinal fluid (CSF). We combined P300 and N200 potentials and reaction time (RT) with CSF biomarkers Aβ1-42, total tau (t-tau), p-tau181, p- tau199, p-tau231, and VILIP-1. Ninety-seven subjects were included in the study including 49 AD patients, 28 patients with mild cognitive impairment (MCI), 4 healthy control subjects, and 16 patients with other primary causes of dementia. Our main finding is a moderate to strong correlation between ERP latency of P300 and N200 potentials and these CSF protein biomarkers. As an isolated biomarker, P300 latency detected early AD most successfully with 90.9% sensitivity and 100% specificity. We also confirmed previous observations of moderate to strong correlation between ERP and neuropsychological testing as well as shortened P300 latency and RT in AD patients treated with acetylcholinesterase inhibitors. Patients with AD were successfully differentiated from patients with frontotemporal dementia using N200 latency and P300 latency. In conclusion, the results of the present study showed that diagnostic efficiency of CSF protein biomarkers Aβ1-42, t-tau, p-tau181, p-tau199, p-tau231, and VILIP-1 could be further improved by adding ERP in clinical practice.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)

POVEZANOST RADA