Naslov
Tau and neurofilament light proteins as biomarkers for perinatal encephalopathy

Autori
Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, kratko priopćenje, ostalo

Izvornik
III. HAZU Simpozij o istraživanjima i bolestima mozga / - Zagreb, 2018, 15-18

Skup
3. HAZU simpozij o istraživanju i bolestima mozga

Mjesto i datum
Zagreb, Hrvatska, 14.03.2018

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
tau protein ; neurofilament protein (neurofilament light chain) ; hypoxic-ischemic encephalopathy ; neonate ; asphyxia ; near-infrared spectroscopy (NIRS) ; magnetic resonance imaging (MRI) ; hypothermia ; umbilical arterial blood gases ; transfontanellar duplex brain ultrasonography ; biomarkers ; early diagnosis ; prognosis

Sažetak
The diagnosis of hypoxic-ischemic encephalopathy in neonates is currently based on clinical symptoms, imaging, and electrophysiological monitoring. Biochemical evaluation of fetal oxygen deprivation (asphyxia) has been traditionally performed using umbilical arterial blood gases at birth, but this test is poorly predictive of injury. Unfortunately, magnetic resonance imaging (MRI) biomarkers also lack early sensitivity for hypoxic injury. Additionally, MRI requires the infant to be moved from the intensive care unit. These hurdles may be eventually overcome with the use of transfontanellar duplex brain ultrasonography, but head ultrasound as an imaging biomarker has relatively low sensitivity and is not universally accepted. In neonatal intensive care units, the regional cerebral tissue oxygen saturation (rScO2) is increasingly being monitored by near-infrared spectroscopy (NIRS), although this method has a limited penetration depth of 1-2 cm and has not been sufficiently validated. To prevent life-long neurological disabilities in neonates with moderate-to-severe perinatal hypoxic-ischemic encephalopathy, hypothermia is currently the only standard treatment. Treatment of neonatal encephalopathy is impeded mainly by the lack of quantifiable biomarkers that could measure the degree of injury, assist in making an optimal treatment protocol, and yield prognostic information. In search for accurate, early predictive markers of fetal asphyxia to direct the clinician as to when to provide neuroprotective therapy, neuronal tau and neurofilament light proteins have been analyzed in the umbilical blood of ten cases of severe-moderate intrapartum asphyxia and in 18 control cases (Toorell et al., J Matern Fetal Neonatal Med, 2018 ; 31:2468-2472). The levels of both tau and neurofilament proteins were significantly higher after asphyxia and correlated with the severity of the neurological deficit. These results are encouraging, but additional studies are needed to assess further the value of blood tau and neurofilament protein levels in clinical practice.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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