Naslov
Combined association of recipient killer cell immunoglobulin-like haplotype AA and donor HLA-C*07 gene with BK virus associated nephropathy in kidney transplant patients
(Combined association of recipient killer cell immunoglobulin-like haplotype AA and donor HLA- C*07 gene with BK virus associated nephropathy in kidney transplant patients)

Autori
Kovačević Vojtušek, Ivana ; Burek Kamenarić, Marija ; Ivković, Vanja ; Bulimbašić, Stela ; Mareković, Ivana ; Ćorić, Marijana ; Bošnjak, Zrinka ; Grubić, Zorana ; Žunec, Renata

Izvornik
HLA (2059-2302) 94 (2019); 4-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
BK virus ; kidney transplantation ; KIR genes

Sažetak
Kidney transplant recipient killer cell immunoglobulin-like receptors (KIR) genotype and HLA-C status of their donors have been separately associated with BK virus-associated nephropathy (BKVAN) and BK virus infection. Our aim was to determine whether different combinations of recipients KIR genes and donor HLAC ligands influence the risk of BKVAN. Retrospective case- control study included 23 recipients with BKVAN and 46 recipients with persistently negative BK virus. Donor HLA-C*07 positivity was associated with lower odds for BKVAN, recipients bearing KIR haplotype AA or lacking any activating KIR genes were more frequent in BKVAN while recipient/donor combination HLA-C*07 negative/KIR AA positive was significantly associated with BKVAN. Our study complements and confirms results from several previously published studies, suggesting potential clinical usefulness.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

POVEZANOST RADA