Naslov
The incidence of congenital malformations of the central nervous system at autopsy

Autori
Jukić, Stanko ; Krušlin, Božo ; Šimić, Goran ; Babić, Damir ; Škrablin, Snježana ; Tkalčević, Tea

Izvornik
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics (1330-0091) 3 (1994); 50-53

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
autopsy ; central nervous system ; abnormalities ; neual tube defects

Sažetak
The autopsy records were retrospectively reviewed of 1898 stillborns and liveborns up to 28 days of age who died in three different 5-year periods (1923-27, 1958-62, and 1987-91, respectively). Types of the central nervous system (CNS) malformations in autopsied infants were: anencephaly (altogether 15 cases analyzed), anencephaly + meningomyelocoele (1 case), anencephaly + craniorachischisis (1), craniorachischisis (3), spina bifida (3), spina bifida + hydrocephalus (4), meningocoele (8), meningocoele + hydrocephalus (2), meningomyelocoele (2), encephalocoele (3), meningomyelocoele (4), meningomyelocoele + hydrocephalus (1), meningocoele + deformatio Arnold-Chiary + hydrocephalus (1), hydrocephalus (22), hydranencephaly (3), hemicrania + cranioschisis partialis (1), holoprosencephaly (4), agenesis corporis callosi (2), micropolygyria (1). The incidence of CNS malformations during the investigated periods was 1.7%, 3.6%, and 5.3%, respectively. CNS malformations represented 16%, 29.2%, and 29.4% of all congenital malformations, respectively. The difference in CNS malformations between the first and the the third period was statistically significant (Chi-squared = 4.68, d.f. = 1, p = 0.03), whereas the differences between the first and the second (Chi-squared = 1.6, d.f. = 1, p = 0.21), and between the second and the third period (Chi-squared = 1.57, d.f. = 1, p = 0.21) were not significant. In all three periods CNS malformations affected more commonly females than males, but this difference was not statistically significant. Causes of malformations were ascertained in 13.4% of all cases (in the last period 15.8% of cases were of known origins). The results indicated that the incidence of CNS malformations in Croatia, especially neural tube defects (NTDs) was higher than 73 years ago.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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