Naslov
Neuroprotective Potential of Natural Compounds against Oxidative Stress-Related Neurodegeneration

Autori
Jazvinšćak Jembrek, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Brain and Mind: Promoting Individual and Community Well-Being - Book of Abstracts / - Zagreb : Hrvatsko katoličko sveučilište, 2019, 92-92

ISBN
978-953-8014-36-9

Skup
2. međunarodni znanstveno-stručni skup: Mozak i um: promicanje dobrobiti pojedinca i zajednice

Mjesto i datum
Zagreb, Hrvatska, 12.12.2019. - 14.12.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Oxidative stress ; Flavonoids ; Neuroprotection ; Safety

Sažetak
Neurodegenerative diseases, such as Alzheimer’s and Parkinson’ disease, are progressive and incurable disorders characterized by neuronal degeneration and ultimately cell death. The incidence of neurodegenerative diseases increases with age, and as the world's population is getting older, they represent a growing medical problem with enormous economic costs and social consequences. Oxidative stress, a condition that is characterized by an increased accumulation of reactive oxygen species, is recognized as one of the most important contributing factors to the common pathophysiology of neurodegenerative diseases, particularly in the period directly preceding the onset of first symptoms. Compelling data suggest that various natural compounds and their extracts possess anti-oxidative activity. Hence, dietary supplements of natural origin are often taken as an adjuvant therapy with the aim to prevent or delay oxidative stress-related neurodegenerative changes. They can easily be obtained at many health food and drug stores. However, the doses and bioavailability of antioxidants in nutraceuticals that contain purified herbal extracts are highly beyond levels associated with a typical diet enriched with fruits and vegetables. Since they are not marketed as drugs but as supplements that improve the overall well-being, natural products are in principle not subjected to rigorous pharmacological and toxicological testing. There is increasing evidence which suggests that prolonged supplementation with certain antioxidants may exert harmful effects. Our results indicate that natural compounds that are appreciated for their antioxidative activities may switch to pro-oxidant action and modulate intracellular signalling pathways in the presence of copper ions. This is particularly interesting as copper-dyshomeostasis is considered an important mechanism contributing to the development and progression of oxidative stress conditions in neurodegeneration. Therefore, further pharmacological and toxicological research must be carried out in order to clarify the neuroprotective efficacy and safety of natural products during prolonged administration in a specific oxidative stress-induced environment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA