Naslov
Liraglutide in Children and Teens with Type 2 Diabetes

Autori
Javor, Eugen ; Skelin, Marko ; Lucijanić, Marko

Izvornik
The New England journal of medicine (0028-4793) 381 (2019), 18; 1786-1787

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
liraglutide ; hypoglycemia

Sažetak
Although it is widely accepted that glucagon- like peptide-1 (GLP-1) receptor agonists do not cause hypoglycemia, 1 the recent Evaluation of Liraglutide in Pediatrics with Diabetes (Ellipse) trial conducted by Tamborlane et al. (Aug. 15 issue)2 appears to call this statement into question. The higher incidence of hypoglycemia in the liraglutide group cannot be explained by a higher proportion of participants using basal insulin at baseline ; the absolute difference is too small to explain the observed effect.However, there could be an imbalance in the proportion of patients who started taking insulin during the trial. Such a difference in proportion might affect not only the difference in the incidence of hypoglycemia but also the difference in glycated hemoglobin levels.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA