Pregled bibliografske jedinice broj: 1034689
Nix phosphorylation and dimerization: two mechanisms of mitophagy activation
Nix phosphorylation and dimerization: two mechanisms of mitophagy activation // FEBS3+ conference "From molecules to living systems"
Siófok, Mađarska, 2018. str. 1-1 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 1034689 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Nix phosphorylation and dimerization: two mechanisms of mitophagy activation
Autori
Marinković, Mija ; Šprung, Matilda ; Rogov, Vladimir ; Dötsch, Volker ; Dikic Ivan ; Novak, Ivana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
FEBS3+ conference "From molecules to living systems"
Mjesto i datum
Siófok, Mađarska, 02.09.2018. - 05.09.2018
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Mitophagy ; dimerization ; phosphorylation ; NIX
Sažetak
Growing evidences of the function of particular autophagy receptors indicate that most of them are often working together in the same selective autophagy pathway, such as aggrephagy, xenophagy and mitophagy. Several mitophagy receptors have been described such as scAtg32, BNIP3 and Bnip3L/Nix that interact with Atg8/LC3/GABARAP family proteins in LIR-dependent manner and recruit autophagy machinery to damaged mitochondria. This research is focused on Bnip3L/Nix receptor and its regulation. Our current results show that phosphorylation and dimerization of mitophagy receptors Nix and Bnip3 are essential for the initiation of mitochondrial sequestration by autophagic machinery and are involved in mitophagy fine-tuning.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-UIP-2013-11-5246 - Uloga receptora autofagije u selektivnom uklanjanju mitohondrija (AutoMito) (Novak Nakir, Ivana, HRZZ ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split
