Naslov
CONTRIBUTION OF FREQUENT HLA-A~B~DRB1 HAPLOTYPES TO DONOR SEARCH OUTCOMES IN CROATIA

Autori
Maskalan, Marija ; Grubić, Zorana ; Sviličić, Danijela ; Štingl Janković, Katarina ; Burek Kamenarić, Marija ; Žunec, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts for the 12th East‐West Immunogenetics Conference, 8–9th March 2018, City Conference Centre, Prague, Czech Republic / Marsh, Steven GE - , 2018, 74-74

Skup
12th East‐West Immunogenetics Conference

Mjesto i datum
Prag, Češka Republika, 08.03.2018. - 09.03.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA-A~B~DRB1 HAPLOTYPES, HSCT, Croatia

Sažetak
Recent studies about HLA polymorphisms in Croatians included HLA haplotype frequency analysis in the Croatian Bone Marrow Registry revealing 50 most common HLAA~ B~DRB1 haplotypes as frequent (>0.1%). The rest of the haplotypes were defined as less frequent (<0.1%) or rare if they included at least one HLA allele observed three times at maximum in our population. This retrospective study included 362 patients transplanted with unrelated donors from 2012 to 2017 in UHC Zagreb. All patients had family derived haplotypes. The aim was to assess the distribution of HLA haplotypes in order to evaluate the probability of finding a donor in the national or international registry. In the group of 73 patients (20.17%) who received a transplant from national donor (group 1), 92 different haplotypes were found while in the group of 289 patients (79.83%) who found an international donor (group 2), the diversity of haplotypes was much higher, with 432 different haplotypes. The HLA-A*01:01~B*08:01~DRB1*03:01 haplotype showed the highest frequency in both groups ; however its presence was significantly higher in group 1 (18.49% and 2.94%, respectively ; P<0.0001). HLA genotypes consisting of two frequent haplotypes, as well as genotypes consisting of one frequent and one less frequent haplotype were significantly more present in group 1 than in group 2 (23.29% vs. 4.84%, P<0.0001 and 60.27% vs. 44.29%, P=0.0179 respectively ; ). Genotypes with both less frequent haplotypes were significantly more frequent in group 2 (47.06% vs. 15.09%, P<0.0001). The same states for the genotypes consisting of one less frequent and one rare haplotype, which we found in six patients with international donors and just one patient with a national donor. The presence of at least one frequent haplotype represents a positive predictive factor for finding a donor in our registry while patients bearing less frequent or rare haplotypes will mostly benefit from finding a donor worldwide.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

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