Naslov
Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure

Autori
Versporten, Ann ; Gyssens, Inge C ; Pulcini, Céline ; Monnier, Annelie A ; Schouten, Jeroen ; Milanič, Romina ; Stanić Benić, Mirjana ; Tebano, Gianpiero ; Le Maréchal, Marion ; Zanichelli, Veronica ; Huttner, Benedikt ; Vlahović-Palčevski, Vera ; Goossens, Herman ; Hulscher, Marlies E ; Adriaenssens, Niels ; Beović, Bojana ; Bavestrello, Luis ; Cohen, Jon ; Cortoos, Pieter-Jan ; Dhillon, Harpal ; Drew, Richard ; Fernandes, Prabhavathi ; Findlay, David ; Friedland, Ian ; Gould, Ian ; Hicks, Lauri ; Longshaw, Christopher ; Llor, Carl ; McGeer, Allison ; Okeke, Iruka N ; Plachouras, Diamantis ; Poulakou, Garyfallia ; Rex, John H ; Tängdén, Thomas ; Saust, Laura Trolle ; Richon, Claudine ; Roblot, France ; Stichele, Robert vander ; Verweij, Marcel ; Wertheim, Heiman ; the DRIVE-AB WP1 group

Izvornik
Journal of antimicrobial chemotherapy (0305-7453) 73 (2018), Suppl_6; Vi59-vi66

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
antibiotics ; intrinsic drive ; outpatients ; consensus

Sažetak
Background The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of ‘responsible’ antibiotic use. Objectives To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA