Pregled bibliografske jedinice broj: 1032862
Forces in bridging fibers segregate chromosomes independently of the attachment to the spindle pole
Forces in bridging fibers segregate chromosomes independently of the attachment to the spindle pole // The EMBO Meeting 2016
Mannheim, Njemačka, 2017. (predavanje, nije recenziran, neobjavljeni rad, znanstveni)
CROSBI ID: 1032862 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Forces in bridging fibers segregate chromosomes independently of the attachment to the spindle pole
Autori
Buđa, Renata ; Vukušić, Kruno ; Bosilj, Agneza ; Milas, Ana ; Pavin, Nenad ; Tolić, Iva M.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
The EMBO Meeting 2016
Mjesto i datum
Mannheim, Njemačka, 10.09.2017. - 13.09.2017
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
anaphase ; bridging fibers ; laser ablation
Sažetak
Using laser ablation laser ablation, we show that in U2OS cells the kinetochores can segregate without the attachment to spindle pole or any other microtubule structure of the spindle. We found that major contribution to kinetochore movement in isolated fibres came from “pacman” depolymerisation and sliding between bridging fibres connecting sister k-fibres, while contribution of poleward flux was negligible. Our results demonstrate that the bridging fibre, while linked to the k-fibres, can contribute to chromosome separation by pushing apart sister kinetochores through sliding mechanism.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb
