Naslov
Synthesis, characterization and self-assembly of small peptidic gelators based on amyloid β-protein

Autori
Frkanec, Leo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Peptide Chemistry Day, Book of Abstracts / Frkanec, Ruža ; Namjesnik, Danijel - Zagreb : University of Zagreb, Croatian Chemical Society, Zagreb, 2019, 6-6

ISBN
978-953-8250-03-3

Skup
Peptide Chemistry Day

Mjesto i datum
Zagreb, Hrvatska, 19.09.2019

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Self-assembly ; Small peptidic gelators ; Amyloid β-protein

Sažetak
Alzheimer's disease is characterized by the extracellular fibrillar deposits of the 39-42 amino acid amyloid-β proteins (Aβ). It was shown that the KLVFF fragment of Aβ- peptide is responsible for the formation of amyloid fibrils. The self-assembly phenomena of the low molecular weight peptides into supramolecular gels show resemblance to amyloid-β protein aggregation and hence may serve as a simple model for A β- aggregation. The series of tripeptide gelators incorporating amino acids sequence present in the Aβ-protein denoted responsible for the protein aggregation have been synthesized and characterized. Tripeptide derivative Ac-FFA-NH2 was capable to self-assemble into hydrogel network at physiological pH. The obtained hydrogel successfully mimics the extracellular matrix and was proved to serve as stable and biocompatible physical support in improving HEK293T cells biological outcome in vitro.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA