Naslov
Women with epilepsy – Reproductive health, pregnancy, delivery and newborn's outcome

Autori
Prpic, Igor ; Mahulja-Stamenkovic, Vesna ; Petrovic, Oleg ; Vukelic, Petar ; Radic Nisevic, Jelena ; Haller, Herman ; Polic, Ljerka ; Ivandic, Jelena

Izvornik
European Journal of Paediatric Neurology (1090-3798) 21 (2017); E188-e188

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
epilepsy ; pregnancy ; reproductive health ; newborn's outcome

Sažetak
Objective: To investigate specific parameters of women with active epilepsy (WwAE) and their early new-born's outcome versus healthy women. Patients and methods: Demographic, anti- conceptional, pregnancy, delivery and new-borns outcome medical data of 230 WwAE were compared with 290 healthy women. Data were collected retrospectively and prospectively during the period of year's 1998–2016. Results: The median age when diagnosis epilepsy was established was 16.7 years. Epilepsy duration longer than 15 years had 36% WwAE, 46% generalized and 54% localization related epilepsy. 74% WwAE were on monotherapy. Median age on delivery was 29.8 years. There were no significant difference regarding education, age of delivery, gynaecological and reproductive history, complications during pregnancy or post-delivery and mode of delivery between WwAE and healthy women. WwAE were significantly lees employed (32%:22%), had more gynaecological examination (10.5:8.9) and foetal ultrasound (7.4:5.5) during pregnancy and more often attended pre- delivery teaching course (35%:14%). There were 231 new-borns of WwAE with no differences between two groups regarding gestational age, birth weight, birth length, head circumference, Apgar score, being small for gestational age and admission to intensive neonatal unit care. Significantly less were breastfeed new-borns of WwAE (76% vs. 92%). There were no significant differences regarding live new-borns with congenital malformations but there were four induced abortions due to foetal malformations in WwAE which give incidence of 6% congenital malformations in WwAE vs 2% in healthy women. Conclusion: Our study revealed that the WwAE have not an increased risk of adverse course of pregnancy, delivery and new-born outcome, except foetal congenital malformations. These results are not in concordance with similar studies. We might explain that with particular health care of WwAE due to good cooperation between the gynecologist-obstetricians, neurologists, neonatologists, neuropediatricians and family physicians in our region, WwAE might have good reproductive health, pregnancy, delivery and newborn's outcome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA