Naslov
High prevalence of Transmitted HIV Drug Resistance Mutations in a cohort of newly diagnosed HIV-infected patients at entrance to care in the period from 2014 to 2016: the Croatian data

Autori
Oroz, Maja ; Planinic, Ana ; Židovec Lepej, Snježana ; Begovac, Josip.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
1st Croatian Congress On Biosafety And Biosecurity

Mjesto i datum
Zagreb, Hrvatska, 07.12.2017. - 09.12.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
HIV-1, primarna rezistencija na antiretrovirusne lijekove
(HIV-1, primary drug resistance)

Sažetak
Croatia has a centralized system of HIV-1 care and all patients are treated at University Hospital for Infectious Diseases “Dr.Fran Mihaljević”. HIV drug- resistance testing is routinely performed for all patients experiencing virological failure and for selected therapy-naive patients. Results of our previous national study showed substantially higher prevalence of transmitted drug resistance mutations(TDRM)of 21.6%(in the period 2006 to 2008, compared with European data, with the prevalence of 8.4%(in the period 2002-2005.Moreover, the study by Grgic et al. determined the highest risk factor for HIV transmission in the group of men who have sex with men(MSM(80/118 patients, 67.8%), who accounted for 76.9% of all transmitted drug resistance cases.Since the acute/recent phase of infection represents the most opportune time to detect transmitted drug resistance(TDR, the goal of the study was to determine the prevalence of TDRM in therapy-naive patients with recently acquired HIV infection, who entered clinical care at our center in the period 2014-2016. Additionally, the evolutionary relationship between nucleotide sequences of patients who carried T215S primary resistance mutation and their possible interconnection with the local T215S transmission cluster was assessed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA