Naslov
Short latency afferent cortical inhibition in obstructive sleep apnea syndome: a TMS study

Autori
Rogić Vidaković, Maja ; Jerković, Ana ; Šoda, Joško ; Vujović, Igor ; Benzon, Benjamin ; Đogaš, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th Croatian Neuroscience Congress : Book of Abstracts / - , 2019, 104-104

Skup
7th Croatian Neuroscience Congress

Mjesto i datum
Zadar, Hrvatska, 12.10.2019. - 15.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
short latency afferent inhibition ; TMS ; MEP

Sažetak
Patients with obstructive sleep apnea syndrome (OSAS) show repetitive upper airway obstructions that occur during sleep and are allied with a reduction in blood oxygen saturation resulting in intermittent hypoxia, sympathetic excitation and sleep fragmentation. OSA is associated with the range of medical conditions such as hypertension, obesity, type 2 diabetes, depression, as well as with psychological and cognitive deficits. However, neurophysiologic mechanisms of OSAS are complex and still obscure. Preliminary evidences of Nardone et al. (Sleep Medicine 2016 ; 24:51-56) point to dysfunctions in cholingeric system assessed by short afferent cortical inhibition (SAI) technique. The SAI phenomena is thought to depend on neural interactions within the cerebral cortex either by inhibition of the motor cortex from fast conducting afferents or via withdrawal of tonic facilitation from thalamic structures. The objective of this exploratory study was to investigate SAI in severe OSAS patients (AHI >30 h-1) by paired- pulse paradigm where conditioning electrical stimuli are applied to the median nerve followed by cortical navigated (nTMS) over the primary motor cortex for hand muscle representation. Magnetic resonance images (MRI) of the head were obtained to suit the TMS requirements and were integrated in the nTMS system and used for the 3D reconstruction of individual’s brain. Motor evoked potentials (MEPs) were recoded from the abductor pollicis brevis (APB) muscle with nTMS conditioned by electrical stimuli applied to the median nerve at the wrist at interstimulus intervals (ISIs) of 18 to 28 ms in a group of seventeen severe OSAS patients, and twelve healthy control subjects. Univariate analysis was performed to identify the differences on SAI between the control group and OSAS patients. The results from this study indicate significant reduction on SAI in severe OSAS patients when compared with controls. The role of SAI as potential marker in early detection and treatment of OSA patients is still to be examined in future studies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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