Disease characteristics and causes of early and late death in a group of Croatian patients with systemic lupus erythematosus deceased over a 10- year period

Padjen, Ivan; Cerovec, Mislav; Erceg, Marijan; Mayer, Miroslav; Stevanović, Ranko; Anić, Branimir

doi:10.3325/cmj.2018.59.3

Pregled bibliografske jedinice broj: 1030656

Disease characteristics and causes of early and late death in a group of Croatian patients with systemic lupus erythematosus deceased over a 10- year period

Padjen, Ivan; Cerovec, Mislav; Erceg, Marijan; Mayer, Miroslav; Stevanović, Ranko; Anić, Branimir

Disease characteristics and causes of early and late death in a group of Croatian patients with systemic lupus erythematosus deceased over a 10- year period // Croatian Medical Journal, 59 (2018), 1; 3-12 doi:10.3325/cmj.2018.59.3 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1030656 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Disease characteristics and causes of early and late death in a group of Croatian patients with systemic lupus erythematosus deceased over a 10- year period

Autori
Padjen, Ivan ; Cerovec, Mislav ; Erceg, Marijan ; Mayer, Miroslav ; Stevanović, Ranko ; Anić, Branimir

Izvornik
Croatian Medical Journal (0353-9504) 59 (2018), 1; 3-12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
systemic lupus

Sažetak
Aim To assess the causes of early death (ED) and late death (LD) in patients with systemic lupus erythematosus (SLE) and determine the features of deceased SLE patients followed-up in a single Croatian tertiary hospital center, because little if any data on causes of death (CODs) in SLE patients are available for Croatia. Method We identified SLE patients regularly followed-up at the Division of Clinical Immunology and Rheumatology, University Hospital Center Zagreb, who died from 2002 to 2011. Death was ascertained by matching our institutional records with the Croatian National Death Database. Patients were grouped according to their disease duration to ED and LD and compared by demographic characteristics, classification criteria, organ damage, and CODs. Results We identified 90 patients (68 women), who died at the age of 58 ± 15 years. The most frequent COD category was cardiovascular diseases (40%), followed by infections (33%), active SLE (29%), and malignancies (17%). No significant difference was found between the frequencies of causes of ED and LD, except for stroke, which caused only LD≥10 years after the diagnosis. SLE was reported in death certificates of only 41 of 90 patients. Conclusion Although stroke occurred both in the early and late disease course, it was primarily associated with LD. Given the low proportion of SLE recorded in death certificates of deceased SLE patients, matching of institutional and vital statistics records may be required to assess the true impact of SLE on mortality

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Miroslav Mayer (autor)