Naslov
The variability of detoxifying GSTP1 gene polymorphisms in the Roma population from Croatia

Autori
Zajc Petranović, Matea ; Špinderk, Sanja ; Stojanović Marković, Anita ; Tomas, Željka ; Škarić-Jurić, Tatjana ; Peričić Salihović, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Genetics & Applications: Special Edition. Book of abstracts - 1st Congress of Geneticists in Bosnia and Herzegovina with International Participation (2nd - 4th October, 2019) / Bajrović, Kasim - Sarajevo : Institute for Genetic Engineering and Biotechnology, Sarajevo, Bosnia and Herzegovina, 2019, 26-26

Skup
1st Congress of Geneticists in Bosnia and Herzegovina with International Participation

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 02.10.2019. - 04.10.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
GSTP1, ADME genes, rs1138272, rs1695, pharmacogenetics, Roma (Gypsy)

Sažetak
The genetic variability of xenobiotic- metabolizing enzymes contributes to individual susceptibility to environmental risk factors (outdoor pollutants, cigarette smoke, diet- related xenobiotics). Glutathione S- transferases (GSTs) are ubiquitous family of multifunctional enzymes which decrease oxidative damage in cells by catalyzing the conjugation of many toxic compounds with glutathione. The GSTP1 is a polymorphic gene whose certain variants, by altering the gene product protein structure, have been investigated as candidate loci involved in the predisposition to pathologic conditions. This study investigated rs1695 (A313G, I105V) and rs1138272 (C341T, A114V) genotypes, alleles and haplotypes in 440 members of three socio- culturally different and geographically distant Roma (Gypsy) groups. The Baranja and the Međimurje Roma groups belong to Vlax (Bayash) Roma who speak Ljimb`d Bayash, while the Balkan Roma group speaks Romani Chib. Haplotypes were inferred using Phase ver. 2.1. Both investigated loci were in Hardy-Weinberg equilibrium in all the three Roma populations. Minor allele frequency (MAF) of rs1138272 was significantly higher in the Baranja (16.4%) and in the Balkan Roma (14.9%) than in the Međimurje Roma (8.8%) (p<0.01 and p<0.05, respectively). The MAF of the rs1695 was significantly higher in the Baranja Roma (35.9%) than in the Balkan Roma (25.0%) (p<0.01). The most prevalent haplotype in all Roma groups was I105-A114, while the second most frequent in the Baranja and the Međimurje Roma was V105-A114 and in the Balkan Roma group V105-V114 (p<0.001). The analyzed GSTP1 polymorphic loci indicate that Balkan Roma significantly differ from the Baranja and the Međimurje Roma, which is in concordance with their specific histories and distant socio-cultural characteristics.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA