Naslov
Prevalence and Clinical Relevance of Occult HCV Infection (OCI) - from a Pathologist's View

Autori
Dmitrović, Branko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Program and Abstracts. 6th International Monothematic Conference on Viral Hepatitis C. / Smolić, Robert ; Včev, Aleksandar ; Wu, George Y - Osijek : University of Osijek, Faculty of Dental Medicine and Health and Croatian Society for Precision (Personalized) Medicine, 2019, 40-40

ISBN
978-953-48243-6-8

Skup
6th International Monothematic Conference on Viral Hepatitis C (IMC-HCV 2019)

Mjesto i datum
Osijek, Hrvatska, 03.10.2019. - 05.10.2019

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
hepatitis C, chronic

Sažetak
Occult HCV Infection (OCI) is a new form of CHC and was introduced by Castillo et al in 2004. OCI is defined as the presence of HCV-RNA in hepatocytes and the absence of HCV in the serum according to usual tests. OCI has been reported in several high-risk groups, especially in hemodialysis patients and subjects with cryptogenic liver disease. Currently, the detection of HCV-RNA in liver tissue (liver biopsies) or in peripheral blood mononuclear cells (PBMCs) occurring in an individual with undetectable HCV-RNA in serum represents the gold standard for the identification of an OCI. Pathohistological evidence of OCI is not convincing, and HCV-RNA identification is not routinely performed. RT-PCR detection of the HCV-RNA in liver biopsy specimens is expensive, unstandardized, and time-consuming. The alternative diagnostics tests should be applied in future. Literature: Pham TNQ, Coffin CS, Michalak TI. Occult hepatitis C virus infection: what does it mean? Liver International 2010 ; 502-11. Attar BM, Van Thiel D. A New Twist to a Chronic HCV Infection: Occult hepatitis C. Gastroenterology Research and Practice 2015 ; 1- 14. Rezaee- Zavareh MS, Hadi R, Karimi-Sari H, et al. Occult HCV infection: The Current State of Knowledge. Iran Red Crescent Med J 2015 ; 17(11):e34181. Austria A, Wu GY. Occult Hepatitis C Virus Infection: A Review. Journal of Clinical and Translational Hepatology 2018 ; 6:155-60.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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