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Pregled bibliografske jedinice broj: 1025085

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Lawson, Michelle A.; McDonald, Michelle M.; Kovacic, Natasa; Hua Khoo, Weng; Terry, Rachael L.; Down, Jenny; Kaplan, Warren; Paton-Hough, Julia; Fellows, Clair; Pettitt, Jessica A. et al.
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche // Nature Communications, 6 (2015), 1; 8983, 15 doi:10.1038/ncomms9983 (međunarodna recenzija, članak, znanstveni)

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Naslov
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Autori
Lawson, Michelle A. ; McDonald, Michelle M. ; Kovacic, Natasa ; Hua Khoo, Weng ; Terry, Rachael L. ; Down, Jenny ; Kaplan, Warren ; Paton-Hough, Julia ; Fellows, Clair ; Pettitt, Jessica A. ; Neil Dear, T. ; Van Valckenborgh, Els ; Baldock, Paul A. ; Rogers, Michael J. ; Eaton, Colby L. ; Vanderkerken, Karin ; Pettit, Allison R. ; Quinn, Julian M. W. ; Zannettino, Andrew C. W. ; Phan, Tri Giang ; Croucher, Peter I.

Izvornik
Nature Communications (2041-1723) 6 (2015), 1; 8983, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
myeloma, bone, dormancy, osteoclasts

Sažetak
Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell- intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it exerts cell-extrinsic control over myeloma cell dormancy and reactivation. In this study, we track individual myeloma cells by intravital imaging as they colonize the endosteal niche, enter a dormant state and subsequently become activated to form colonies. We demonstrate that dormancy is a reversible state that is switched ‘on' by engagement with bone-lining cells or osteoblasts, and switched ‘off' by osteoclasts remodelling the endosteal niche. Dormant myeloma cells are resistant to chemotherapy that targets dividing cells. The demonstration that the endosteal niche is pivotal in controlling myeloma cell dormancy highlights the potential for targeting cell- extrinsic mechanisms to overcome cell-intrinsic drug resistance and prevent disease relapse.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Profili:

Avatar Url Nataša Kovačić (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Lawson, Michelle A.; McDonald, Michelle M.; Kovacic, Natasa; Hua Khoo, Weng; Terry, Rachael L.; Down, Jenny; Kaplan, Warren; Paton-Hough, Julia; Fellows, Clair; Pettitt, Jessica A. et al.
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche // Nature Communications, 6 (2015), 1; 8983, 15 doi:10.1038/ncomms9983 (međunarodna recenzija, članak, znanstveni)
Lawson, M., McDonald, M., Kovacic, N., Hua Khoo, W., Terry, R., Down, J., Kaplan, W., Paton-Hough, J., Fellows, C. & Pettitt, J. (2015) Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. Nature Communications, 6 (1), 8983, 15 doi:10.1038/ncomms9983.
@article{article, author = {Lawson, Michelle A. and McDonald, Michelle M. and Kovacic, Natasa and Hua Khoo, Weng and Terry, Rachael L. and Down, Jenny and Kaplan, Warren and Paton-Hough, Julia and Fellows, Clair and Pettitt, Jessica A. and Neil Dear, T. and Van Valckenborgh, Els and Baldock, Paul A. and Rogers, Michael J. and Eaton, Colby L. and Vanderkerken, Karin and Pettit, Allison R. and Quinn, Julian M. W. and Zannettino, Andrew C. W. and Phan, Tri Giang and Croucher, Peter I.}, year = {2015}, pages = {15}, DOI = {10.1038/ncomms9983}, chapter = {8983}, keywords = {myeloma, bone, dormancy, osteoclasts}, journal = {Nature Communications}, doi = {10.1038/ncomms9983}, volume = {6}, number = {1}, issn = {2041-1723}, title = {Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche}, keyword = {myeloma, bone, dormancy, osteoclasts}, chapternumber = {8983} }
@article{article, author = {Lawson, Michelle A. and McDonald, Michelle M. and Kovacic, Natasa and Hua Khoo, Weng and Terry, Rachael L. and Down, Jenny and Kaplan, Warren and Paton-Hough, Julia and Fellows, Clair and Pettitt, Jessica A. and Neil Dear, T. and Van Valckenborgh, Els and Baldock, Paul A. and Rogers, Michael J. and Eaton, Colby L. and Vanderkerken, Karin and Pettit, Allison R. and Quinn, Julian M. W. and Zannettino, Andrew C. W. and Phan, Tri Giang and Croucher, Peter I.}, year = {2015}, pages = {15}, DOI = {10.1038/ncomms9983}, chapter = {8983}, keywords = {myeloma, bone, dormancy, osteoclasts}, journal = {Nature Communications}, doi = {10.1038/ncomms9983}, volume = {6}, number = {1}, issn = {2041-1723}, title = {Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche}, keyword = {myeloma, bone, dormancy, osteoclasts}, chapternumber = {8983} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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