Naslov
Elevated Neutrophil–to–Lymphocyte-ratio and Platelet–to–Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself?

Autori
Lucijanić, Marko ; Čičić, David ; Štoos‑Veić, Tajana ; Pejša, Vlatko ; Lucijanić, Jelena ; Fazlić Džankić, Amina ; VLasac Glasnović, Josipa ; Sorić, Ena ; Skelin, Marko ; Kušec, Rajko

Izvornik
Anticancer Research (0250-7005) 38 (2018), 5; 3157-3163

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
philadelphia chromosome negative myeloproliferative neoplasm ; primary myelofibrosis ; secondary myelofibrosis ; inflammatory biomarkers ; survival

Sažetak
Background/Aim: We aimed to investigate clinical associations of inflammatory biomarkers neutrophil- tolymphocyte- ratio (NLR) and platelet-to- lymphocyte-ratio (PLR) in patients with myelofibrosis, myeloproliferative neoplasm with inflammatory background. Patients and Methods: We retrospectively analyzed a cohort of 102 myelofibrosis patients. NLR and PLR were assessed in addition to other diseasespecific parameters. Results: NLR and PLR were significantly higher in myelofibrosis than in healthy controls. Higher NLR was significantly associated with Janus-kinase- 2 (JAK2)- mutation, wild-type-Calreticulin (CALR), older age and parameters reflecting increased proliferative potential of disease (higher leukocytes, higher hemoglobin, larger spleensize), whereas there was no significant association with C-reactive-protein (CRP). Higher PLR was significantly associated with absence of blast-phase-disease, absence of constitutional-symptoms, lower percentage-of- circulatoryblasts, smaller spleen-size and lower CRP. In the Coxregression- model, higher- NLR (HR=2.76 ; p=0.004), lower- PLR (HR=1.99 ; p=0.042) and Dynamic- International- Prognostic- System (DIPSS) (HR=3.26 ; p<0.001) predicted inferior survival independently of each other. Conclusion: In the context of myelofibrosis, elevated NLR and PLR are more likely to represent myeloproliferation itself and not necessary the extent of inflammation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA