Naslov
Antiproliferative evaluation of various aminoquinoline derivatives

Autori
Zorc, Branka ; Rajić, Zrinka ; Perković, Ivana

Izvornik
Acta pharmaceutica (1330-0075) 69 (2019); 661-672

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
primaquine, chloroquine, mefloquine, fumardiamide, antiproliferative activity

Sažetak
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA