Toxicity of pharmaceuticals in binary mixtures: assessment by additive and non-additive toxicity models

Ukić, Šime; Sigurnjak, Marija; Cvetnić, Matija; Markić, Marinko; Novak Stankov, Mirjana; Rogošić, Marko; Rasulev, Bakhtiyor; Lončarić Božić, Ana; Kušić, Hrvoje; Bolanča, Tomislav

doi:10.1016/j.ecoenv.2019.109696

Pregled bibliografske jedinice broj: 1020732

Toxicity of pharmaceuticals in binary mixtures: assessment by additive and non-additive toxicity models

Ukić, Šime; Sigurnjak, Marija; Cvetnić, Matija; Markić, Marinko; Novak Stankov, Mirjana; Rogošić, Marko; Rasulev, Bakhtiyor; Lončarić Božić, Ana; Kušić, Hrvoje; Bolanča, Tomislav

Toxicity of pharmaceuticals in binary mixtures: assessment by additive and non-additive toxicity models // Ecotoxicology and environmental safety, 185 (2019), 109696, 9 doi:10.1016/j.ecoenv.2019.109696 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1020732 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Toxicity of pharmaceuticals in binary mixtures: assessment by additive and non-additive toxicity models

Autori
Ukić, Šime ; Sigurnjak, Marija ; Cvetnić, Matija ; Markić, Marinko ; Novak Stankov, Mirjana ; Rogošić, Marko ; Rasulev, Bakhtiyor ; Lončarić Božić, Ana ; Kušić, Hrvoje ; Bolanča, Tomislav

Izvornik
Ecotoxicology and environmental safety (0147-6513) 185 (2019); 109696, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
toxicity ; pharmaceuticals ; binary mixtures ; concentration addition ; independent action

Sažetak
Current risk assessment in many countries, including European Union, is still placing focus on single substances rather than their mixtures, although mixtures are commonly found in the environment. To overcome this problem and gain new insights, six pharmaceuticals, namely: azithromycin (AZM), erythromycin (ERM), carbamazepine (CBA), oxytetracycline (OTC), dexamethasone (DXM), and diclofenac (DCF), were selected in order to analyze their combined toxicity in binary mixtures. Overall, 45 binary mixtures were analyzed. Single component toxicities were determined as well, for modeling purpose. Two most common mathematical models for the description of mixture toxicities were applied: concentration addition (CA) and independent action (IA) model. Comparison of the predicted and experimentally obtained toxicities provided information about the modes of toxicity action in the mixtures. OTC–DCF binary mixture indicated synergism with respect to additive behavior (CA model). All other binary combinations containing OTC or DCF were acting very similarly: the synergism with respect to additive behavior was observed for OTC–CBA and DCF-CBA combinations, while OTC–AZM, OTC–ERM, DCF–AZM and DCF–ERM exhibited antagonistic behavior with respect to CA model. All the remaining binary mixtures indicated additive behavior. The applicability of IA model as a proof of independent toxic action of the components was confirmed in cases of DCF–AZM, DCF–ERM, and OTC–AZM mixtures.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne tehničke znanosti

POVEZANOST RADA

Projekti:
HRZZ-IP-2014-09-7992 - Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala (MEAoWT) (Bolanča, Tomislav, HRZZ ) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Matija Cvetnić (autor)