Naslov
Photodynamic activity of free-base and Zn(II) complexes of N-methylated tetra- and tripyridylporphyrins

Autori
Mušković, Martina ; Ratkaj, Ivana ; Malatesti, Nela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
6th Young Medicinal Chemist Symposium

Mjesto i datum
Atena, Grčka, 05.09.2019. - 06.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Photodynamic therapy ; Zn(II) complexes ; Porphyrins ; Lipophilicity ; Singlet oxygen

Sažetak
Photodynamic therapy (PDT) is a relatively new, minimally invasive therapeutic procedure that is based on a cytotoxic effect against malignant cells using three main components, photosensitiser (PS), light and oxygen. Porphyrins and other related tetrapyrrole molecules present highly investigated group of PSs for PDT, due to their characteristic photophysical and photochemical properties. Some of their desirable properties are stability, negligible or no toxicity in dark, absorption and fluorescence spectra in visible region and efficient production of the singlet oxygen (1O2)[1]. Another useful characteristic of porphyrins is a relatively easy chelation on their pyrrole nitrogen atoms that leads to different photophysical and photochemical properties in comparison to free- base porphyrins. It was shown that chelation with Zn(II) and other paramagnetic metals could increase the lifetime of the PS’s excited triplet state (3PS*), which increases the possibility of 3PS* to react with molecular oxygen and cellular targets. Chelation can also change the lipophilicity of the molecule, thus it could have two possible ways in improving PDT activity of the PS[2]. Since it was proven that the presence of alkyl chain and overall amphiphilicity plays an important role for PDT[3], the impact of chain length as well as Zn(II) chelation of N-methylated pyridylporphyrins was further investigated[4]. Their photophysical and photochemical properties relevant for use in PDT, such as absorption and fluorescence spectra, singlet oxygen production using 1, 3-diphenylisobenzofurane (DPBF) fluorescence decrease method, and lipophilicity using Rf value and n-butanol/water partition coefficient methods will be presented[4]. Finally, photodynamic activity and dark toxicity of both free-base and Zn(II) pyridylporphyrins against melanoma cells will be presented as a part of a study of the effect of a chain length and chelation with Zn(II).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA