Naslov
Interferon-alpha and ribavirin treatment in patients with chronic hepatitis C and normal aminotransferase values

Autori
Pavić, Tajana ; Duvnjak, Marko ; Virović Lucija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Acta medica Croatica / Knežević, Stojan ; Duvnjak, Marko ; Beritić-Stahuljak, Dunja - Zagreb : Akademija medicinskih znanosti Hrvatske, 2001

Skup
3. kongres Hrvatskog gastroenterološkog društva s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 23.09.2001. - 26.09.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
chronic hepatitis C; treatment; interferon-alpha; ribavirin; normal aminotransferase values

Sažetak
Aim: to evaluate the efficacy of combination therapy with interferon-alpha (IFN-alpha) an ribavirin in patients with chronic hepatitis C and normal aminotransferase values. Patients and methods: 12 HCV RNA positive patients (7 males and 5 females, mean age 38, 1 years) with normal or near-normal aminotransferase values on three consecutive occasions and histologically mild disease were included in the study. During the induction period of 4 weeks they received 5 MU IFN-alfa 2b and ribavirin 1000 mg daily. Following 44 weeks they received 3 MU IFN-alfa 2b thrice weekly with ribavirin 1000 mg daily. Serum HCV RNA was tested every three months during treatment, at the end of therapy (end-of-treatment response) and 6 months afterwards (sustained virological response). Results: 7 of 12 patients (58%) cleared the virus at the end of therapy and 5 of 12 (42%) showed sustained virological response. No significant elevation of aminotransferase values was detected during IFN therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA