Naslov
Cardiac Obesity and Cardiac Cachexia: Is There a Pathophysiological Link?

Autori
Selthofer-Relatić, Kristina ; Kibel, Aleksandar ; Delić-Brkljačić, Diana ; Bošnjak, Ivica

Izvornik
Journal of Obesity (2090-0708) 2019 (2019); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cachexia, heart failure, obesity

Sažetak
Obesity is a risk factor for cardiometabolic and vascular diseases like arterial hypertension, diabetes mellitus type 2, dyslipidaemia, and atherosclerosis. A special role in obesity- related syndromes is played by cardiac visceral obesity, which includes epicardial adipose tissue and intramyocardial fat, leading to cardiac steatosis ; hypertensive heart disease ; atherosclerosis of epicardial coronary artery disease ; and ischemic cardiomyopathy, cardiac microcirculatory dysfunction, diabetic cardiomyopathy, and atrial fibrillation. Cardiac expression of these changes in any given patient is unique and multimodal, varying in clinical settings and level of expressed changes, with heart failure development depending on pathophysiological mechanisms with preserved, midrange, or reduced ejection fraction. Progressive heart failure with misbalanced metabolic and catabolic processes will change muscle, bone, and fat mass and function, with possible changes in the cardiac fat state from excessive accumulation to reduction and cardiac cachexia with a worse prognosis. *e question we address is whether cardiac obesity or cardiac cachexia is to be more feared.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA