Naslov
Comparison of Surgisis, Vypro II and TiMesh in contaminated and clean field

Autori
Filipović-Čugura, Jakša ; Misir, Zvonimir ; Hrabač, Pero ; Orešić, Tomislav ; Vidović, Dinko ; Misir, Branimir ; Filipović, Nika ; Kirac, Iva ; Mijić, August

Izvornik
Hernia (1265-4906) 24 (2019), 3; 551-558

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hernia ; infection ; rat model ; surgisis ; timesh ; Vypro II

Sažetak
The study aimed to evaluate the histologic properties and infection resistance of three different mesh materials in a rat model. Each mesh, in both infectious (n = 96) and non- infectious groups (n = 270), was positioned both in sublay (preperitoneally) and onlay (subcutaneously) locations. Properties of the biological (Surgisis ; Cook Surgical), composite, partially resorbing (Vypro II mesh ; Ethicon) and non-resorbing (TiMesh ; GFE Medizintechnik GmbH) mesh were evaluated and compared. Animals were killed at 7, 21 and 90 days after implantation. The following parameters were evaluated to assess the host response to the mesh material: inflammation, vascularization, fibrosis, collagen formation, Ki67, and a foreign body reaction by granuloma formation (FBG). Surgisis mesh produced more pronounced inflammation and cell proliferation, and less intense granuloma formation, as well as fibrosis, compared to the other two groups. When the infected materials were examined, we found signs of local infection to be more often present in Surgisis group of animals. CONCLUSIONS: In the presence of bacterial contamination, no benefits were observed in the use of the Surgisis prosthesis over the use of TiMesh and Vypro II.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA