Naslov
Mechanisms of Hepatic Cholestatic Drug Injury

Autori
Omanović Kolarić, Tea ; Ninčević, Vjera ; Smolić, Robert ; Smolić, Martina ; Wu, George Y

Izvornik
Journal of Clinical and Translational Hepatology (2225-0719) 7 (2019), 1; 86-92

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Drug-induced liver injury, Bile acids, Cholestasis

Sažetak
Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA