Naslov
HCV Extrahepatic Manifestations.

Autori
Kuna, Lucija ; Jakab, Jelena ; Smolić, Robert ; Wu, George Y ; Smolić, Martina

Izvornik
Journal of clinical and translational hepatology (2225-0719) 7(2) (2019); 172-182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Keywords: Hepatitis C virus, Hepatic stellate cells, B cell lymphomas, pancreatic B cell, TGF-β-dependent signaling pathway, Extrahepatic manifestations, Direct-acting antivirals

Sažetak
Abstract: Hepatitis C virus (HCV) has been shown to affect many tissues other than liver. However, of the many extrahepatic manifestations (EMs) that have been associated with HCV, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes and neurological disorders, only a few have been shown to be directly related to HCV infection of extrahepatic tissues. HCV-triggered immune- mediated mechanisms account for most of the EMs. It is estimated that up to 74% of patients with chronic hepatitis C can develop at least one EM. All HCV patients with EMs should be considered for antiviral therapy, although not all will resolve with sustained virological response.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA