Naslov
Association of Wnt Inhibitors, Bone Mineral Density and Lifestyle Parameters in Women with Breast Cancer Treated with Anastrozole Therapy

Autori
Bojanić, Kristina ; Bilić Ćurčić, Ines ; Kuna, Lucija ; Kizivat, Tomislav ; Smolić, Robert ; Raguž, Lučić Nikola ; Kralik, Kristina ; Šerić, Vatroslav ; Ivanac, Gordana ; Tucak-Zorić, Sandra ; Včev, Aleksandar ; Smolić, Martina.

Izvornik
Journal of Clinical Medicine (2077-0383) 17 ; 7(9) (2018); 1-12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Wnt signaling pathway ; aromatase inhibitors ; bone density ; breast neoplasms

Sažetak
Abstract: Aim: To determine the levels of Wnt inhibitors in patients treated with aromatase inhibitors (AIs) prior to therapy and to investigate their association with bone mineral density (BMD) and lifestyle parameters. Methods: 137 breast cancer patients were divided into a group treated with 1 mg of anastrozole and a group w/o anastrozole therapy. Serum concentrations of sclerostin and dickkopf1 (DKK1) were measured by ELISA. BMD was measured by dual-energy X-ray absorptiometry (DXA). Lifestyle factors were investigated by a self-reported questionnaire. Results: Sclerostin was significantly higher in the AI-treated group (31.8 pmol/L vs. 24.1 pmol/L ; p < 0.001), whereas DKK1 was significantly lower in the AI-treated group (24.3 pmol/L vs. 26.02 pmol/L ; p < 0.001). Total hip and femoral neck BMD were significantly lower in the AI-treated group. Conclusion: AI treatment was associated with increased levels of sclerostin and decreased levels of DKK1

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA