Naslov
Biochemical Characterization of Naturally Occurring HPV-16 E6 and E7 Variants

Autori
Đukić, Anamaria ; Thatte Jayashree Vijay ; Božinović, Ksenija ; Dediol, Emil ; Grce, Magdalena ; Banks, Lawrence ; Tomaić, Vjekoslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Power of Viruses / Bielen, Ana ; Ježić, Marin ; Jurak, Igor ; Škorić, Dijana ; Tomiać, Vjekoslav - Zagreb : Hrvatsko mikrobiološko društvo, 2018, 69-69

ISBN
978-953-7778-15-6

Skup
The conference Power of Viruses

Mjesto i datum
Poreč, Hrvatska, 16.05.2018. - 18.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Human papillomavirus ; E6 oncoprotein ; E6 variants ; cancer ; transformation

Sažetak
There are approximately 200 Human papillomaviruses (HPV) which infect humans and a small number of them were shown to be the causative agents of numerous human tumors, with cervical cancer being the most important disease. They are referred to as high risk types and of these HPV-16 and -18 are associated with the majority of HPV-induced malignancies. The two major oncoproteins, E6 and E7, which are encoded by these viruses are directly responsible for the development of the cancers. Among the high risk types, HPV-16 is the most potent viral type in causing cancer. There are however many of HPV-16 variants found in various geographical locations, and they were shown to differ in their abilities to cause cancer. It is clear that some of these variants are more frequently found in cancers than the other variants, implying some likely very important differences in their oncogenic potentials to drive malignant progression. The molecular mechanisms responsible for an increased cancer risk of a number of HPV-16 variants are however still poorly defined.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA