Naslov
Flavonoid loaded mesoporous silica nanoparticles as potential drug carriers

Autori
Sadžak, Anja ; Mandić, Lucija ; Šegota, Suzana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Solid State Science & Research Meeting - Book of abstracts / - , 2019, 71-71

Skup
Solid State Science and Research Meeting

Mjesto i datum
Zagreb, Hrvatska, 27.06.2019. - 29.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
flavonoids ; lipid peroxidation ; nanoparticles ; antioxidants ; silica

Sažetak
Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is limited by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin, and myricitrin have been investigated to determine the relationship between flavonoid structure and protective activity towards oxidative stress, i.e., lipid peroxidation induced by the addition of hydrogen peroxide and combination of hydrogen peroxide and copper(II) ions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA