Naslov
Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer

Autori
Draško Tomić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the 41 Int. Convention Mipro / - Opatija, 2018, 0275-0278

Skup
41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO 2018)

Mjesto i datum
Opatija, Hrvatska, 21.05.2018. - 25.05.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
anticancer herbal compounds , in silico models of cancer , hallmarks of cancer , oncogene proteins , interaction between molecules

Sažetak
There is a mounting evidence that certain herbal compounds express strong activity against various types of cancer cells. Curcumin from Curcuma longa, resveratrol from Vitis vinifera, and artemisinin from Artemisia annua are few examples from the longer list of more than fifty anticancer herbs known. This is mostly due to the extreme complexity of cancer processes that an exact mechanism of anticancer activity of these compounds is still unknown. However, with the rise of powerful supercomputers and the advanced in silico models of cancer, our chances to understand these processes increased, and now we are in place to deliver more effective therapies than ever before. KEGG (Kyoto Encyclopedia of Genes and Genomes) cancer pathways are example of such in silico models. From KEGG cancer pathways, we were able to identify sixty-two oncogene proteins involved in the development, proliferation, angiogenesis, metastasis and resistance of cancer. From them, we selected those having the largest number of hits in Pubmed database related to each of these cancer hallmarks, and use supercomputer for docking simulations between them and certain anticancer herbal compounds. Significant activity of anticancer herbal compounds against oncogene proteins was found. We hope our research will setup pathways towards more effective therapies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA